The effect of the nimesulide and a new 4-thiazolidinone derivative on hematological parameters in the conditions of an experimental inflammatory process

The aim of the work was to identify anti-inflammatory effect a newly synthesized drug from group 4-thiazolidinones. Thus, comparative study two agents conducted: Les6490 and non-steroidal nimesulide. This belongs drugs (NSAIDs), which have pronounced anti-inflammatory, analgesic antipyretic effects. Nimesulide highly selective inhibitors cyclooxygenase its isoenzymes (COX-2) is used for treatment in various pathologies musculoskeletal system. compound 4-thiazolidinone derivatives. thiazolidinone ring part many existing potential antibacterial agents, can be combined with pyrazole fragments, are pharmacophores same structure, contribute increased therapeutic efficacy. peculiarities hematological changes rats during experimental reproduction associated inflammatory process using Freund’s adjuvant model has been conducted. As result activity based on indicators — new derivative 4-thiazolidinones nonsteroidal nimesulide their revealed, considered comparable slight advantage Les6490. At time, without affecting quantitative level erythrocytes isolated administration, under conditions process, caused significant increase total number erythrocytes. No amount found. analysis leukocyte formula suggests evidence that some extent more than most AF-induced inflammation were observed neutrophils: studied substance compared introduction partially normalization monocytes, AF-associated no observed.